Open AccessRelationship between magnetism and prion protein
Author(s) -
Francesca Balzano,
Marco Zedda,
M. Basagni,
Silvia Dei Giudici,
Andrea Danani,
Vinod K. Sanna
Publication year - 2010
Publication title -
journal of biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 6
eISSN - 2284-0230
pISSN - 1826-8838
DOI - 10.4081/jbr.2010.4434
Subject(s) - prion protein , gene isoform , magnetism , chemistry , biology , microbiology and biotechnology , biophysics , biochemistry , pathology , physics , medicine , condensed matter physics , gene , disease
The mechanism of conversion of the normal prion protein (PrPC) into aggregates of its pathological conformer (PrPSc) reamins unclear. The aim of this study was to evaluate the effects induced by exposure of biological samples containing PrPSC to a magnetic field induced prominent molecular changes of samples indicated by the IR spectra located in the region that contains contribution primarily from absorption of amides. This finding suggests the existence of a strong correlation between magnetism and PrPsc and supports a new hypothesis that explains the conversion of normal PrPc to abnormal isoform PrPsc