Open AccessUse of electrophoresis for the determination of protein polymorphisms: application to the study of isolated human populations
Author(s) -
N. Salis,
Ε. Rabino Massa
Publication year - 2009
Publication title -
journal of biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 6
eISSN - 2284-0230
pISSN - 1826-8838
DOI - 10.4081/jbr.2009.4775
Subject(s) - haptoglobin , transferrin , biology , principal component analysis , properdin , genetics , computational biology , immunology , statistics , complement system , antibody , mathematics , biochemistry
Third factor of complements (C3), group specific component (Gc), properdin B factor (Bf), haptoglobin (Hp) and transferrin (Tf) polymorphisms were studied in a mountain communities samples from the Italian-French Alps. Electrophoresis was used to determine the seroprotein systems, since both traditional and high-resolution methods have proved to be valid tools in anthropogenetic investigations. Principal components analysis and maximum likelihood estimation were used to analyse the genetic relationships among populations