Open AccessGstm1 and Gstt1 Genotypes and Chromosomal Damage in Subjects Exposed to Low Level of Formaldehyde
Author(s) -
Maria Paola Bigatti,
Laura Lamberti,
Alfredo Santovito,
G. Ardito
Publication year - 2003
Publication title -
journal of biological research
Language(s) - English
Resource type - Journals
eISSN - 2284-0230
pISSN - 1826-8838
DOI - 10.4081/jbr.2003.10546
Subject(s) - glutathione , biology , xenobiotic , genotype , detoxification (alternative medicine) , gene , genetics , enzyme , glutathione transferase , detoxication , biochemistry , medicine , alternative medicine , pathology
During the course of evolution, the living organisms have developed a set of enzymes able to eliminate the harmful xenobiotics present in food and in the environment (1). Among the several detoxification mechanisms (phase II) used for protection, the reduced glutathione and the glutathione-S-transferases (GSTs) is one of the most efficient systems. At least five gene families are present in humans (GSTM,GSTT,GSTP,GSTA and microsomal GST). In humans at least twenty GST enzymes with different isoenzymatic forms are present. Both GSTM1 and GSTT1, in particular, are polymorphic and there is now a considerable volume of data supporting the opinion that these polymorphisms can influence the susceptibility to cancer. [...]