Open AccessSimulated Microgravity Induces Apoptosis in Human Lymphocytes by a 5-Lipoxygenase-Mediated Mechanism
Author(s) -
M. Maccarrone,
N. Battista,
M. A. Meloni,
M. Bari,
G. Galleri,
P. Pippia,
A. Cogoli,
A. Finazzi-Agrò
Publication year - 1970
Publication title -
journal of biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 6
eISSN - 2284-0230
pISSN - 1826-8838
DOI - 10.4081/jbr.2003.10528
Subject(s) - jurkat cells , apoptosis , spaceflight , microbiology and biotechnology , biology , programmed cell death , signal transduction , lipoxygenase , weightlessness , immune system , immunology , biochemistry , enzyme , t cell , physics , astronomy , engineering , aerospace engineering
Experiments performed during spaceflight clearly show that several cellular processes, such as oxidative metabolism, growth rates, signaling pathways and gene expression, are modified under conditions of weightlessness [1]. In particular, it has been suggested that reduced growth response in lymphocytes during spaceflight might be linked to apoptosis, based on morphological detection and cDNA microarray analysis [2] of space-flown human lymphoblastoid (Jurkat) cells. 5-Lipoxygenase (arachidonate:oxygen 5-oxidoreductase, EC 1.13.11.34; 5-LOX) plays a central role in interleukin-2 expression and activation of human lymphocytes, and is involved in the initiation of programmed death (apoptosis) triggered by unrelated stimuli in different human cells (reviewed in ref. 3). [...]