Open AccessIn Situ Hybridization for the Identification of Karyotype Anomalies in the Histological Analysis of Early Spontaneous Abortion
Author(s) -
F. Grillo,
C. Ivaldi,
M. Curto
Publication year - 1970
Publication title -
journal of biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 6
eISSN - 2284-0230
pISSN - 1826-8838
DOI - 10.4081/jbr.2003.10518
Subject(s) - abortion , karyotype , trisomy , monosomy , biology , products of conception , gestation , obstetrics , gynecology , pregnancy , chromosome , genetics , medicine , gene
An estimated 15% of known pregnancies terminate in spontaneous abortion, the majority (90% circa) within the XII° week of gestation: early spontaneous abortion (ESA). Spontaneous abortions are either occasional (first abortion in the patient’s reproductive history), repeated (the second) or habitual (third or more).The possible causes are many, but about half are due to alterations in embryonic karyotype – 27% trisomy, 10% polipolidy, 9% monosomy and 2% structural rearrangements [1]. With histological examination a morphological diagnosis of chromosomal anomalies may be suspected, based on structural anomalies of the villous tree or alterations in vascularization, but a cytogenetic confirmation is required [2]. [...]