Open AccessEndocardial Endothelium and Cardiac Contractility
Author(s) -
G. Alloatti
Publication year - 1970
Publication title -
journal of biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 6
eISSN - 2284-0230
pISSN - 1826-8838
DOI - 10.4081/jbr.2003.10513
Subject(s) - endothelium , contractility , medicine , prostacyclin , nitric oxide , endothelin receptor , endocardium , vasomotor , paracrine signalling , endothelin 1 , cardiology , endocrinology , biology , receptor
Following the observation by Furchgott and Zawadski (1980) about the obligatory role of vascular endothelium in vasomotor tone, several in vitro and in vivo studies provided experimental evidences that cardiac endothelium plays a similar role in regulating cardiac function.Modulation of contractility by endothelial cells has first described for the endocardial endothelium (EE), and was then extended to vascular endothelium in the myocardial capillaries (VEMC). It has been shown that EE and VEMC release paracrine messangers such as nitric oxide (NO), endothelin and prostacyclin, both in basal conditions and under mechanical or chemical stimulation. [...]