Open AccessEndothelial Dysfunction and Vascular Preconditioning
Author(s) -
R. Rastaldo
Publication year - 1970
Publication title -
journal of biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 6
eISSN - 2284-0230
pISSN - 1826-8838
DOI - 10.4081/jbr.2003.10512
Subject(s) - cardiology , ischemia , stunning , medicine , myocardial infarction , necrosis , endothelium , endothelial dysfunction , occlusion , reperfusion injury , coronary artery occlusion , infarction , myocardial stunning , artery
The prolonged occlusion of a coronary artery followed by reperfusion causes deleterious effects known as “ischemiareperfusion injuries”. In fact, these injuries,which affect both myocardium and coronary endothelium, initiate during ischemia and worsen during reperfusion.Thus, although myocardial infarction is the necrosis occurring as a consequence of the ischemia, its size can increase with reperfusion.Usually two hours of reperfusion are sufficient to induce a noticeable increase in size of the infarct area. In addition to necrosis, also myocardial stunning and arrhythmias are features of the damage. [...]