Open AccessSex differences in adverse drug reaction and liver disease
Author(s) -
Ombretta Para,
Pietro Crispino,
Nunzia Barone,
Sara Macis,
Laura Airasca,
Paola Gnerre,
Cecilia Politi
Publication year - 2018
Publication title -
italian journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.134
H-Index - 10
eISSN - 1877-9352
pISSN - 1877-9344
DOI - 10.4081/itjm.2018.893
Subject(s) - medicine , cirrhosis , epidemiology , disease , drug , adverse effect , steatohepatitis , drug reaction , liver disease , adverse drug reaction , hepatitis , alcoholic liver disease , public health , intensive care medicine , fatty liver , pharmacology , pathology
Adverse drug reactions represent a significant public health problem. A share of no small adverse reaction is particularly serious and can even lead to patient’s death. Furthermore, hepatitis induced by serious drug reactions is a rare event but potentially fatal. Finally, we know that epidemiological studies have highlighted male gender as an independent predictor of fibrosis progression towards cirrhosis in hepatitis B and C-virus, as well as non-alcoholic steatohepatitis. The importance of considering the differences between the male and female sex in clinical decision-making is crucial. The physiopathology of liver disease is different in the two genres, but these differences are not yet fully known and several potential mechanisms have been identified.