Open AccessBiomarkers for sepsis: past, present and future
Author(s) -
Giuseppe Chesi,
Natale Vazzana,
Claudio Giumelli
Publication year - 2016
Publication title -
italian journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.134
H-Index - 10
eISSN - 1877-9352
pISSN - 1877-9344
DOI - 10.4081/itjm.2016.795
Subject(s) - medicine , intensive care medicine , sepsis , context (archaeology) , septic shock , antibiotics , antibiotic stewardship , risk stratification , etiology , clinical practice , antibiotic therapy , antibiotic resistance , family medicine , paleontology , microbiology and biotechnology , biology
Sepsis is a complication of severe infection associated with high mortality and open diagnostic issues. Treatment strategies are currently limited and essentially based on prompt recognition, aggressive supportive care and early antibiotic treatment. In the last years, extensive antibiotic use has led to selection, propagation and maintenance of drug-resistant microorganisms. In this context, several biomarkers have been proposed for early identification, etiological definition, risk stratification and improving antibiotic stewardship in septic patient care. Among these molecules, only a few have been translated into clinical practice. In this review, we provided an updated overview of established and developing biomarkers for sepsis, focusing our attention on their pathophysiological profile, advantages, limitations, and appropriate evidence-based use in the management of septic patients