Open AccessAgranulocytosis: an adverse effect of allopurinol treatment
Author(s) -
E Mari,
Franco Ricci,
Davide Imberti,
Massimo Gallerani
Publication year - 2013
Publication title -
italian journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.134
H-Index - 10
eISSN - 1877-9352
pISSN - 1877-9344
DOI - 10.4081/itjm.2011.120
Subject(s) - allopurinol , medicine , hyperuricemia , xanthine oxidase inhibitor , leukopenia , adverse effect , xanthine oxidase , bone marrow suppression , anemia , neutropenia , side effect (computer science) , gastroenterology , toxicity , uric acid , biochemistry , chemistry , programming language , computer science , enzyme
Allopurinol is a xanthine oxidase inhibitor that is primarily used to treat hyperuricemia and its complications. The drug is rarely associated with adverse effects, but those that occur can be significant. Hematologic side effects, including bone marrow suppression, severe anemia, thrombocytopenia, and leukopenia, have been reported in 0.2-0.6% of treated patients. Materials and methods: We report a case of agranulocytosis associated with allopurinol therapy in a patient admitted for fever