Open AccessThe Chaperonopathies - Diseases with Defective Molecular Chaperones
Author(s) -
Giovanni Li Volti
Publication year - 2013
Publication title -
european journal of histochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 42
eISSN - 2038-8306
pISSN - 1121-760X
DOI - 10.4081/ejh.2013.br15
Subject(s) - nobel laureate , ribonuclease , protein folding , folding (dsp implementation) , biochemistry , protein tertiary structure , chemistry , computational biology , enzyme , biology , philosophy , rna , linguistics , engineering , gene , poetry , electrical engineering
In the mid 1950's the Nobel Prize Laureate Christian B. Anfinsen from his research on the folding of ribonuclease A, began to concentrate on the problem of the relationship between structure and function in enzymes. On the basis of studies on ribonuclease, he proposed that the information determining the tertiary structure of a protein resides in the chemistry of its amino acid sequence...