Open AccessNiemann-Pick disease, type B with TRAP-positive storage cells and secondary sea blue histiocytosis
Author(s) -
Prashant Sharma,
Rakhee Kar,
Shyamali Dutta,
Hara Prasad Pati,
Renu Saxena
Publication year - 2009
Publication title -
european journal of histochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 42
eISSN - 2038-8306
pISSN - 1121-760X
DOI - 10.4081/ejh.2009.e22
Subject(s) - niemann–pick disease , disease , pathology , medicine , chemistry
We present 2 cases of Niemann Pick disease, type B with secondary sea-blue histiocytosis. Strikingly, in both cases the Pick cells were positive for tartrate resistant acid phosphatase, a finding hitherto described only in Gaucher cells. This report highlights the importance of this finding as a potential cytochemical diagnostic pitfall in the diagnosis of Niemann Pick disease