Open AccessUse of CytoSorb in the emergency department-high dependency unit: A case report and a mini review
Author(s) -
Emanuela Biscardi,
Giuseppe Carpinteri,
Pietro Castellino,
Lorenzo Malatino
Publication year - 2021
Publication title -
emergency care journal
Language(s) - English
Resource type - Journals
eISSN - 2282-2054
pISSN - 1826-9826
DOI - 10.4081/ecj.2021.9825
Subject(s) - medicine , septic shock , hemoperfusion , sepsis , emergency department , intensive care unit , intensive care medicine , extracorporeal membrane oxygenation , renal replacement therapy , extracorporeal , anesthesia , hemodialysis , psychiatry
Circulating inflammatory mediators and cytokines play a pivotal role in the progression of sepsis, leading in turn to septic shock, organ failure and resistance to standard therapy. Blood purification therapies may be adjuvant treatment for severe sepsis, but results have been shown to be so far controversial. Recently, CytoSorb has achieved promising outcomes on reduction of cytokine blood levels, improvement of clinical parameters and mortality in sepsis, as well as in other acute conditions. It is mostly used in Intensive Care Unit (ICU), in isolated hemoperfusion, or inserted in other circuits in addition to Continuous Renal Replacement Therapy (CRRT), heart-lung machines and extracorporeal membrane oxygenation. We report a case of septic shock occurred in our Emergency Department-High Dependency Unit (ED-HDU), resistant to standard therapy and improved after CytoSorb, so avoiding ICU hospitalization.