Open AccessImmunohistochemical expression of interleukin 1 beta in papule biopsies from patients with acne vulgaris
Author(s) -
Le Thai Van Thanh,
Le Vi Anh,
Tran Huong Giang,
Ta Quoc Hung,
Van The Trung,
Nguyen Lam Vuong
Publication year - 2022
Publication title -
dermatology reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.183
H-Index - 10
eISSN - 2036-7406
pISSN - 2036-7392
DOI - 10.4081/dr.2022.9444
Subject(s) - acne , papule , medicine , immunohistochemistry , biopsy , skin biopsy , pathology , disease , dermatology , gastroenterology , lesion
Background: Acne vulgaris is the most common inflammatory disease of the skin. IL-1b has been found in acne lesions and is a promising target for therapy, but the evidence is limited. Therefore, this study was conducted to investigate the immunohistochemical expression of IL-1b in papule biopsies of inflammatory acne and its association with disease severity. Methods: This study involved 20 patients with acne vulgaris (13 females, median age: 22 years). Samples were taken using punch biopsy. Immunohistochemical IL-1b expression was semiquantitatively assessed as absent, mild, moderate or strong. Disease severity was evaluated according to the Global Acne Grading System (GAGS). Results: There were 7 patients with mild disease and 11 patients with moderate disease. Median GAGS score was 20. Mild and moderate accounted for 65% and 30% for dermal IL-1b expression, 60% and 40% for epidermal expression, and 70% and 15% for perifollicular expression. Moderatestrong perifollicular expression had significant higher GAGS score than absent-mild expression (median: 22 versus 16). Conclusions: This study shows the elevated immunoreactivity of IL-1b in papule biopsies of inflammatory acne vulgaris. The levels of IL-1b expression also correlates with disease severity. IL- 1b could be a good candidate for targeting treatment of acne vulgaris.