Open AccessPigmentary Mammary Paget Disease: clinical, dermoscopical and histological challenge
Author(s) -
Angelo Massimiliano D’Erme,
Roberta Iozzo,
Paolo Viacava,
Filomena De Luca,
Agata Janowska,
Valentina Dini,
Marco Romanelli,
Cristian Fidanzi,
Giovanni Bagi
Publication year - 2021
Publication title -
dermatology reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.183
H-Index - 10
eISSN - 2036-7406
pISSN - 2036-7392
DOI - 10.4081/dr.2021.9235
Subject(s) - medicine , histopathology , asymptomatic , pathology , lesion , biopsy , melanoma , immunohistochemistry , areola , dermatology , cancer research
A very rare variant of MPD is the Pigmented Mammary Paget Disease (PMPD), first described by Culberson et al. in 1956. It is very difficult to distinguish this variant from melanoma both clinically and dermoscopically. The diagnosis is confirmed by histopathology and immunohistochemistry. Correct diagnosis is crucial for surgical treatment, which is different for these two diseases. We report the case of a 92-year-old woman, who presented an asymptomatic pigmented lesion of the right nipple and areola. The lesion was arisen for about 6 months and was suspected for melanoma because of clinical and dersmoscopic characteristics. Incisional biopsy revealed tumor cells, that proliferate in the major mammary ducts, and tumor cells in the overlying epidermis of the nipple, thus diagnosing pigmented mammary Paget disease (PMPD). The patient underwent radical mastectomy.