Open AccessIn silico experiments as a tool to reduce preclinical tests of magnetic hyperthermia
Author(s) -
Marta Vicentini,
Marta Vassallo,
Riccardo Ferrero,
A. Manzin
Publication year - 2021
Publication title -
biomedical science and engineering
Language(s) - English
Resource type - Journals
ISSN - 2531-9892
DOI - 10.4081/bse.2021.199
Subject(s) - in silico , hyperthermia , magnetic nanoparticles , magnetic field , magnetic hyperthermia , function (biology) , biomedical engineering , materials science , nanotechnology , nanoparticle , chemistry , biology , medicine , microbiology and biotechnology , physics , biochemistry , quantum mechanics , gene
In silico models can be useful tools to guide preclinical tests of magnetic hyperthermia, which employs Magnetic Nanoparticles (MNPs) excited by AC magnetic fields, as heat mediators for cancer cure. We virtually reproduce the heating process induced by magnetic hyperthermia in murine models, as a function of field applicator features, properties and size of target tissue, MNP dose and animal size.