Elucidating molecular connetion between IAHSP onset and Alsin protein by means of Homology Modelling and Molecular Dynamics | Zendy

Marcello Miceli | Zendy; Cécile Exertier | Zendy; Beatrice Vallone | Zendy; Marco Cavaglià | Zendy; Marco A. Deriu | Zendy

Open Access

Elucidating molecular connetion between IAHSP onset and Alsin protein by means of Homology Modelling and Molecular Dynamics

Author(s) -

Marcello Miceli,

Cécile Exertier,

Beatrice Vallone,

Marco Cavaglià,

Marco A. Deriu

Publication year - 2021

Publication title -

biomedical science and engineering

Language(s) - English

Resource type - Journals

ISSN - 2531-9892

DOI - 10.4081/bse.2021.183

Subject(s) - biology , homology modeling , protein folding , homology (biology) , computational biology , folding (dsp implementation) , genetics , microbiology and biotechnology , gene , biochemistry , engineering , electrical engineering , enzyme

The Infantile-onset Ascending Hereditary Spastic Paralysis (IAHSP) is an incurable rare neurodegerative disease related to a mutation-driven aberrant behaviour of the Alsin protein. The lack of information on Alsin atomic structure limits a complete understanding on pathology mechanisms. In this work, molecular modelling techniques have been applied to shed lights on Alsin folding dynamics and misfunction induced by aberrant mutations.

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