Open AccessElucidating molecular connetion between IAHSP onset and Alsin protein by means of Homology Modelling and Molecular Dynamics
Author(s) -
Marcello Miceli,
Cécile Exertier,
B. Vallone,
Marco Cavaglià,
Marco Agostino Deriu
Publication year - 2021
Publication title -
biomedical science and engineering
Language(s) - English
Resource type - Journals
ISSN - 2531-9892
DOI - 10.4081/bse.2021.183
Subject(s) - biology , homology modeling , protein folding , homology (biology) , computational biology , folding (dsp implementation) , genetics , microbiology and biotechnology , gene , biochemistry , engineering , electrical engineering , enzyme
The Infantile-onset Ascending Hereditary Spastic Paralysis (IAHSP) is an incurable rare neurodegerative disease related to a mutation-driven aberrant behaviour of the Alsin protein. The lack of information on Alsin atomic structure limits a complete understanding on pathology mechanisms. In this work, molecular modelling techniques have been applied to shed lights on Alsin folding dynamics and misfunction induced by aberrant mutations.