Open AccessDrug-induced hepatotoxicity studied in a 3D, <em>in vitro</em> model of the liver
Author(s) -
G Guagliano,
Manuela Legnardim,
Cristina Volpini,
Nora Bloise,
Silvia Dotti,
Riccardo Villa,
Livia Visai,
Paola Petrini
Publication year - 2021
Publication title -
biomedical science and engineering
Language(s) - English
Resource type - Journals
ISSN - 2531-9892
DOI - 10.4081/bse.2021.172
Subject(s) - in vitro , drug , pharmacology , clinical trial , drug development , chemistry , medicine , biochemistry
Drug development is a high failure rate process; too many drugs fail during clinical trials because of severe hepatotoxicity. This situation can be significantly improved by redesigning preclinical trials, and privileging the use of high-throughput in vitro models, by combining cell-based in vitro models and material-based models.