Open AccessDevelopment and characterization of a novel human 3D model of bone metastasis from breast carcinoma <em>in vitro</em> cultured
Author(s) -
Deyanira Contartese,
Francesca Salamanna,
Veronica Borsari,
Stefania Pagani,
Matteo Sartori,
Lúcia Martini,
Giovanni Barbanti Bròdano,
A. Gasbarrini,
Milena Fini
Publication year - 2021
Publication title -
biomedical science and engineering
Language(s) - English
Resource type - Journals
ISSN - 2531-9892
DOI - 10.4081/bse.2021.165
Subject(s) - breast carcinoma , metastasis , ex vivo , breast cancer , in vitro , bone metastasis , human breast , in vivo , carcinoma , cancer research , breast cancer metastasis , mammary carcinoma , tumor microenvironment , pathology , medicine , cancer , oncology , biology , biochemistry , microbiology and biotechnology
Breast cancer frequently metastasizes to the skeleton causing significant morbidity. Here, we set-up a novel and advanced ex vivo model by using fresh tissue from human vertebral bone metastasis from breast carcinoma patients able to retain the tumor microenvironment and tumor cells heterogeneity.