Open Access3F(eature)s model: modularity, heterogeneity and three-dimensionality to design <em>in vitro</em> neuronal model
Author(s) -
Martina Brofiga,
Marietta Pisano,
Mariateresa Tedesco,
Francesca Callegari,
Paolo Massobrio
Publication year - 2021
Publication title -
biomedical science and engineering
Language(s) - English
Resource type - Journals
ISSN - 2531-9892
DOI - 10.4081/bse.2021.158
Subject(s) - in vitro , hippocampal formation , modular design , modularity (biology) , neuroscience , electrophysiology , chemistry , computer science , biological system , biology , biochemistry , genetics , operating system
In this work, we present a novel experimental platform to build in vitro interconnected (i.e., modular) heterogeneous (e.g., cortical-hippocampal) and three-dimensional (3D) neuronal cultures plated on Micro-Electrode Arrays (MEAs) to extracellularly record the electrophysiological activity continuously.