Open AccessSuperoxide dismutase 1 (SOD1) and cadmium: a three models approach to the comprehension of its neurotoxic effects
Author(s) -
Federica Bovio,
Barbara Sciandrone,
Chiara Urani,
P. Fusi,
Matilde Forcella,
Maria Elena Regonesi
Publication year - 2021
Publication title -
biomedical science and engineering
Language(s) - English
Resource type - Journals
ISSN - 2531-9892
DOI - 10.4081/bse.2021.157
Subject(s) - sod1 , superoxide dismutase , cadmium , caenorhabditis elegans , recombinant dna , chemistry , antioxidant , microbiology and biotechnology , biology , biochemistry , gene , organic chemistry
In three different biological models, the recombinant protein expressed in E. coli, the neuronal cells SH-SY5Y and the nematode Caenorhabditis elegans, cadmium inhibits SOD1 activity without affecting its expression level.