Open AccessHow systems biology of cancer signaling pathways can inform optimized combination chemotherapy design
Author(s) -
Jack A. Tuszyński,
Edward A. Rietman
Publication year - 2021
Publication title -
biomedical science and engineering
Language(s) - English
Resource type - Journals
ISSN - 2531-9892
DOI - 10.4081/bse.2021.143
Subject(s) - systems biology , computational biology , cancer chemotherapy , cancer therapy , signal transduction , biology , cancer , computer science , bioinformatics , microbiology and biotechnology , genetics
This talk presents an overview of the systems biology of cancer applied to specific protein-protein interaction signaling pathways. We argue that network analysis augmented with thermodynamics measures such as Gibbs free energy can lead to optimized design of drug combinations for cancer chemotherapy.