Open AccessIVTech: The next generation of <me>in vitro</em> models
Author(s) -
Tommaso Sbrana
Publication year - 2021
Publication title -
biomedical science and engineering
Language(s) - English
Resource type - Journals
ISSN - 2531-9892
DOI - 10.4081/bse.2021.139
Subject(s) - in vitro , computer science , human cell , animal model , computational biology , microbiology and biotechnology , biology , genetics , endocrinology
In vitro cell cultures are often proposed as “Alternatives” to animal models, but they are still inadequate to reproduce the human pathophysiology. This is mainly due to the technological limitations of the standard equipment used in cell culture laboratories, such as the lack of a 3D micro-architecture, the static environment and the absence of cross talk between different tissues. These limitations cause the poor predictivity of a standard in-vitro model, if compared with the human reality.