Open AccessPlatelet rich plasma enhancement of skin regeneration in an ex vivo human experimental model
Author(s) -
G. Nicoletti,
Marco Saler,
Laura Villani,
Agnese Rumolo,
Marco Mario Tresoldi,
Angela Faga
Publication year - 2020
Publication title -
biomedical science and engineering
Language(s) - English
Resource type - Journals
ISSN - 2531-9892
DOI - 10.4081/bse.2019.98
Subject(s) - ex vivo , regeneration (biology) , in vivo , wound healing , platelet rich plasma , human skin , platelet , in vitro , microbiology and biotechnology , chemistry , immunology , medicine , biology , biochemistry , genetics
An original ex vivo wounded skin culture protocol using autologous Platelet Rich Plasma (PRP) and enriched Dulbecco’s Modified Eagle’s Medium demonstrated a favourable modulation of the epithelial cells and fibroblasts proliferation, a relevant antiinflammatory action and a favourable modulation of the re-organization of collagen and elastic fibres. The step by step regenerative effects of PRP on human skin wound repair and regeneration process was observed over a period of 10 days.