Platelet rich plasma enhancement of skin regeneration in an ex vivo human experimental model | Zendy

G. Nicoletti | Zendy; Marco Saler | Zendy; Laura Villani | Zendy; Agnese Rumolo | Zendy; Marco Mario Tresoldi | Zendy; Angela Faga | Zendy

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Platelet rich plasma enhancement of skin regeneration in an ex vivo human experimental model

Author(s) -

G. Nicoletti,

Marco Saler,

Laura Villani,

Agnese Rumolo,

Marco Mario Tresoldi,

Angela Faga

Publication year - 2020

Publication title -

biomedical science and engineering

Language(s) - English

Resource type - Journals

ISSN - 2531-9892

DOI - 10.4081/bse.2019.98

Subject(s) - ex vivo , regeneration (biology) , in vivo , wound healing , platelet rich plasma , human skin , platelet , in vitro , microbiology and biotechnology , chemistry , immunology , medicine , biology , biochemistry , genetics

An original ex vivo wounded skin culture protocol using autologous Platelet Rich Plasma (PRP) and enriched Dulbecco’s Modified Eagle’s Medium demonstrated a favourable modulation of the epithelial cells and fibroblasts proliferation, a relevant antiinflammatory action and a favourable modulation of the re-organization of collagen and elastic fibres. The step by step regenerative effects of PRP on human skin wound repair and regeneration process was observed over a period of 10 days.

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