Open AccessHydrogel-based platforms to mimic in vivo drug diffusion: A multicenter research
Author(s) -
Paola Petrini,
Daniela Pacheco,
Francesco BriaticoVangosa,
Cosmin Butnarasu,
Livia Visai,
Orietta Monticelli,
Laura Pastorino,
Sonja Visentin
Publication year - 2020
Publication title -
biomedical science and engineering
Language(s) - English
Resource type - Journals
ISSN - 2531-9892
DOI - 10.4081/bse.2019.101
Subject(s) - mucus , computer science , in vivo , throughput , diffusion , computational biology , biology , microbiology and biotechnology , physics , ecology , telecommunications , wireless , thermodynamics
An airway mucus model is proposed thus serving as an in vitro screening tool with the aim to reduce the number of noneffective drugs reaching the preclinical trials. The engineered mucus model is an easy-to-use and easy-to-produce tool that can be easily coupled to state-of-art diffusion models and it is compatible with high throughput analysis. This platform will serve as the basis to implement the complexity of the model in terms of components, also including the effect of bacteria