Open AccessMuscle pathology in upper motor neuron paraplegia
Author(s) -
R Scelsi,
Paola Poggi
Publication year - 2010
Publication title -
european journal of translational myology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.271
H-Index - 6
eISSN - 2037-7460
pISSN - 2037-7452
DOI - 10.4081/bam.2010.1-2.17
Subject(s) - paraplegia , medicine , skeletal muscle , spinal cord injury , motor neuron , microcirculation , muscle atrophy , physical medicine and rehabilitation , muscle biopsy , spinal cord , pathology , anatomy , biopsy , radiology , disease , psychiatry
During the last 30 years acceptance of the muscle biopsy by paraplegic patients have accumulated a large body of knowledge on effects of spinal cord injury (SCI) on the skeletal muscle microstructure. Light and electron microscopy analyses combined with computerized methods provided a large body of knowledge on the progression of muscle atrophy and on the effects of rehabilitation strategies. Beside a summary of normal human muscle results, we will here discuss the time-course of muscle events related to SCI affecting the upper motor neuron. Furthermore the concomitant events on the microcirculation of skeletal muscle will be described in relation to the frequent complications of deep venous thrombosis, decubitus ulcers and paraosteoarthrosis