Open AccessPotential prognostic value of miR-132 and miR-212 expression in mCRPC patients
Author(s) -
Mariano Pontico,
Viviana Frantellizzi,
Luca Cindolo,
Giuseppe De Vincentis
Publication year - 2021
Publication title -
archivio italiano di urologia andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.429
H-Index - 23
eISSN - 2282-4197
pISSN - 1124-3562
DOI - 10.4081/aiua.2021.3.373
Subject(s) - microrna , prostate cancer , carcinogenesis , angiogenesis , biology , cancer research , pathogenesis , cancer , expression (computer science) , bioinformatics , computational biology , gene , genetics , immunology , computer science , programming language
To the Editor, we have been very pleased to read the interesting work proposed by Salemi et al. regarding the expression of specific fragments of microRNA (miRNA), particularly miR-132 and miR-212, as potential key regulators in prostate cancer (PCa). As outlined by the Authors, the altered expression of miRNAs in cancer pathogenesis represents a well-consolidated knowledge in the current literature. More specifically, both miR-212 and miR-132 regulate subsets of genes involved in tumor progression in several tumor cell types as PCa, proving a central role in tumorigenesis, cell adhesion, and angiogenesis. In addition, a strong association between miR-132 expression and high Gleason score PCa has been lately depicted [...].