Open AccessProspective study to compare antibiosis versus the association of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract in preventing urinary tract infections in patients submitted to urodynamic investigation
Author(s) -
Giovanni Palleschi,
Antonio Carbone,
Pier Paolo Zanello,
R Mele,
Andrea Leto,
Andrea Fuschi,
Yazan Al Salhi,
G. Velotti,
Samer Al Rawashdah,
Gianluca Coppola,
Angela Maurizi,
Serena Maruccia,
Antonio Luigi Pastore
Publication year - 2017
Publication title -
archivio italiano di urologia andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.429
H-Index - 23
eISSN - 2282-4197
pISSN - 1124-3562
DOI - 10.4081/aiua.2017.1.45
Subject(s) - medicine , urinary system , urine , antibiotics , prospective cohort study , surgery , gastroenterology , microbiology and biotechnology , biology
The abuse of antimicrobical drugs has increased the resistance of microorganisms to treatments, thus to make urinary tract infections (UTIs) more difficult to eradicate. Among natural substances used to prevent UTI, literature has provided preliminary data of the beneficial effects of D-mannose, N-acetylcysteine, and Morinda citrifolia fruit extract, due to their complementary mechanism of action which contributes respectively to limit bacteria adhesion to the urothelium, to destroy bacterial pathogenic biofilm, and to the anti-inflammatory and analgesic activity. The purpose of this study was to compare the administration of an association of D-mannose, N-acetylcysteine (NAC) and Morinda citrifolia extract versus antibiotic therapy in the prophylaxis of UTIs potentially associated with urological mini-invasive diagnostics procedures, in clinical model of the urodynamic investigation.