Open AccessThe Role of Histone Acetylation in Mesenchymal Stem Cell Differentiation
Author(s) -
Sujeong Jang,
Jinsu Hwang,
Han-Seong Jeong
Publication year - 2022
Publication title -
chonnam medical journal
Language(s) - English
Resource type - Journals
eISSN - 2233-7385
pISSN - 2233-7393
DOI - 10.4068/cmj.2022.58.1.6
Subject(s) - acetylation , hdac11 , histone deacetylase 5 , histone , microbiology and biotechnology , hdac4 , histone deacetylase , epigenetics , mesenchymal stem cell , cellular differentiation , histone deacetylase 2 , epigenetic regulation of neurogenesis , histone h2a , histone methyltransferase , biology , genetics , gene
The mechanism and action concerning epigenetic modifications, especially that of histone modifications, are not fully understood. However, it is clear that histone modifications play an essential role in several biological processes that are involved in cell proliferation and differentiation. In this article, we focused on how histone acetylation may result in differentiation into mesenchymal stem cells as well as histone acetylation function. Moreover, histone acetylation followed by the action of histone deacetylase inhibitors, which can result in the differentiation of stem cells into other types of cells such as adipocytes, chondrocytes, osteocytes, neurons, and other lineages, were also reviewed.