Open AccessBone Cell Communication Factors Provide a New Therapeutic Strategy for Osteoporosis
Author(s) -
Jung Ha Kim,
Nacksung Kim
Publication year - 2020
Publication title -
chonnam medical journal
Language(s) - English
Resource type - Journals
eISSN - 2233-7385
pISSN - 2233-7393
DOI - 10.4068/cmj.2020.56.2.94
Subject(s) - bone resorption , bone remodeling period , osteoclast , bone remodeling , osteoblast , medicine , osteoporosis , paracrine signalling , bone cell , microbiology and biotechnology , bone formation , resorption , bone density conservation agents , bone density , chemistry , biology , biochemistry , receptor , in vitro
Bone homeostasis is strictly regulated by the balance between bone resorption by osteoclasts and bone formation by osteoblasts. Many studies have shown that osteoclasts affect osteoblasts, and vice versa, through diffusible paracrine factors, cell-cell contact, and cell-bone matrix interactions to achieve the correct balance between osteoclastic and osteoblastic activities in the basic multicellular unit (BMU). The strict regulation that occurs during bone remodeling hinders the long-term use of the currently available antiresorptive agents and anabolic agents for the treatment of osteoporosis. To overcome these limitations, it is necessary to develop novel agents that simultaneously inhibit bone resorption, promote bone formation, and decouple resorption from formation. Therefore, a more detailed understanding of the mechanisms involved in osteoclast-osteoblast communication during bone remodeling is necessary.