Open AccessMitochondrial Ca2+ homeostasis in health and disease
Author(s) -
Michelangelo Campanella,
Paolo Pinton,
Rosario Rizzuto
Publication year - 2004
Publication title -
biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.127
H-Index - 55
eISSN - 0717-6287
pISSN - 0716-9760
DOI - 10.4067/s0716-97602004000400022
Subject(s) - homeostasis , mitochondrion , organelle , biology , microbiology and biotechnology , repertoire , cell , genetics , physics , acoustics
Although it has long been known that mitochondria possess a complex molecular repertoire for accumulating and releasing Ca2+, only in recent years has a large body of data demonstrated that these organelles promptly respond to Ca(2+)-mediated cell stimulations. In this contribution, we will review the principles of mitochondrial Ca2+ homeostasis and its signaling role in different physiological and pathological conditions.