Open AccessRedox regulation of RyR-mediated Ca2+ release in muscle and neurons
Author(s) -
Cecilia Hidalgo,
Ricardo Bull,
María I. Behrens,
P Donoso
Publication year - 2004
Publication title -
biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.127
H-Index - 55
eISSN - 0717-6287
pISSN - 0716-9760
DOI - 10.4067/s0716-97602004000400007
Subject(s) - ryanodine receptor , redox , intracellular , microbiology and biotechnology , biophysics , chemistry , cysteine , endogeny , biochemistry , skeletal muscle , extracellular , biology , enzyme , anatomy , organic chemistry
Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca(2+)-induced Ca2+ release, whereas reducing agents have the opposite effects. We will discuss here how modifications of highly reactive cysteine residues by endogenous redox agents or cellular redox state influence RyR channel activation by Ca2+ and ATP or inhibition by Mg2+. Possible physiological and pathological implications of these results on cellular Ca2+ signaling will be addressed as well.