Open AccessWnt signaling: A complex issue
Author(s) -
Bart S. Hendriks,
Rolf Ernst
Publication year - 2002
Publication title -
biological research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.127
H-Index - 55
eISSN - 0717-6287
pISSN - 0716-9760
DOI - 10.4067/s0716-97602002000200019
Subject(s) - wnt signaling pathway , multicellular organism , hedgehog , biology , cell fate determination , fibroblast growth factor , microbiology and biotechnology , signal transduction , notch signaling pathway , cell , genetics , receptor , gene , transcription factor
The development of tissues and organs in multicellular organisms is controlled by the interplay of several signaling pathways that cross-talk to provide positional information and induce cell fate specification. Together with other families of secreted factors such as TGF beta s, FGFs, Hedgehog and Notch proteins, Wnt growth factors are crucially implicated in these processes. Here, we will first discuss molecular mechanisms and then consider some biological consequences of Wnt signaling.