Open AccessIn vitro approach to the chemical drive of breathing
Author(s) -
Jaime Eugenı́n,
Isabel Llona,
Claudia D. Infante,
Estíbaliz Ampuero
Publication year - 2001
Publication title -
biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.127
H-Index - 55
eISSN - 0717-6287
pISSN - 0716-9760
DOI - 10.4067/s0716-97602001000200016
Subject(s) - in vitro , spinal cord , neuroscience , breathing , respiratory center , biology , respiratory system , rhythm , psychology , medicine , anatomy , genetics
Since its introduction two decades ago, the isolated brain stem-spinal cord preparation of neonatal rodents has been the preferred method used to reveal the mystery underlying the genesis of the respiratory rhythm. Little research using this in vitro approach has focused on the study of the central respiratory chemosensitivity. Some unexpected findings obtained with the brain stem-spinal cord preparation have added new questions that challenge our previous theoretic framework. Some of these findings are addressed here.