Open AccessImmune mediated crescentic MPGN secondary to HBV infection: A rare presentation for a common infection
Author(s) -
Aswani Srinivas Mareddy,
Dharshan Rangaswamy,
Mahesha Vankalakunti,
Ravindra Prabhu Attur,
Shankar Prasad Nagaraju,
Koti Neeraja
Publication year - 2016
Publication title -
the australasian medical journal
Language(s) - English
Resource type - Journals
ISSN - 1836-1935
DOI - 10.4066/amj.2015.2568
Subject(s) - medicine , plasmapheresis , immunosuppression , membranoproliferative glomerulonephritis , renal biopsy , hepatitis b virus , immunology , biopsy , glomerulonephritis , cryoglobulinemia , proteinuria , pathology , kidney , hepatitis c virus , virus , antibody
Hepatitis B virus (HBV) infection presenting as crescentic glomerulonephritis in the absence of cryoglobulinemia is an extremely rare phenomenon. We report a case of a 44-year-old male with HBV infection, who underwent kidney biopsy for rapidly progressive renal failure and nephrotic range proteinuria. Histopathological evaluation of the kidney biopsy was consistent with immune complex mediated crescentic membranoproliferative glomerulonephritis (MPGN). The patient achieved complete renal and virological remission with steroids, plasmapheresis and antiviral therapy. This case report summarises the importance of early initiation of immunosuppression and plasmapheresis under antiviral coverage for improved clinical outcomes.