Open AccessMyeloid-Derived Suppressor Cells Recruited by Chemokine (C-C Motif) Ligand 3 Promote the Progression of Breast Cancer via Phosphoinositide 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin Signaling
Author(s) -
Anqi Luo,
Min Meng,
Guanying Wang,
Rui Han,
Yujiao Zhang,
Xin Jing,
Lin Zhao,
Shanzhi Gu,
Xinhan Zhao
Publication year - 2020
Publication title -
journal of breast cancer/journal of breast cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 36
eISSN - 2092-9900
pISSN - 1738-6756
DOI - 10.4048/jbc.2020.23.e26
Subject(s) - cancer research , ccl3 , pi3k/akt/mtor pathway , chemokine , tumor microenvironment , protein kinase b , metastasis , cell migration , chemokine receptor , chemistry , biology , signal transduction , medicine , immunology , microbiology and biotechnology , cancer , cell , ccl2 , inflammation , biochemistry , tumor cells
Numerous studies have shown that the frequency of myeloid-derived suppressor cells (MDSCs) is associated with tumor progression, metastasis, and recurrence. Chemokine (C-C motif) ligand 3 (CCL3) may be secreted by tumor cells and attract MDSCs into the tumor microenvironment. In the present study, we aimed to explore the molecular mechanisms whereby CCL3 is involved in the interaction of breast cancer cells and MDSCs.