A report of haploidentical allogeneic haematopoietic stem cell transplantation for inherited bone marrow failure in Sri Lanka | Zendy

Wasanthi Wickramasinghe | Zendy; Revathi Raj | Zendy; Shama Goonatillake | Zendy; Anuja Abayadeera | Zendy; Malik Samarasinghe | Zendy; Jeewaka Galhenage | Zendy; Pavithra Aarewatte | Zendy; Devan Mendis | Zendy; Chandima Thevarapperuma | Zendy; Ruwangi Dissanayake | Zendy; Lallindra Gooneratne | Zendy

Open Access

A report of haploidentical allogeneic haematopoietic stem cell transplantation for inherited bone marrow failure in Sri Lanka

Author(s) -

Wasanthi Wickramasinghe,

Revathi Raj,

Shama Goonatillake,

Anuja Abayadeera,

Malik Samarasinghe,

Jeewaka Galhenage,

Pavithra Aarewatte,

Devan Mendis,

Chandima Thevarapperuma,

Ruwangi Dissanayake,

Lallindra Gooneratne

Publication year - 2022

Publication title -

ceylon medical journal

Language(s) - English

Resource type - Journals

eISSN - 2386-1274

pISSN - 0009-0875

DOI - 10.4038/cmj.v67i1.9554

Subject(s) - medicine , sri lanka , sibling , transplantation , disease , haematopoiesis , bone marrow transplantation , stem cell , human leukocyte antigen , hematopoietic stem cell transplantation , bone marrow , pediatrics , surgery , immunology , genetics , psychology , developmental psychology , ethnology , south asia , antigen , biology , history

Bone marrow failure (BMF) in children can be idiopathic (70-80%) or inherited. Haematopoietic stem cell transplantation (HSCT) is the only cure for both causes. Allogeneic HSCT requires a suitable donor. Many children will not have a HLA matched sibling or unrelated donor. A haploidentical donor is available for all children as eaazch parent will have at minimum a 50% HLA match. This report of a 7-year old girl with BMF treated with a haplo-HSCT, the first in Sri Lanka, highlights the importance of developing a haploidentical HSCT programme as a potential cure for a disease with a dismal outcome.

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