Open AccessA report of haploidentical allogeneic haematopoietic stem cell transplantation for inherited bone marrow failure in Sri Lanka
Author(s) -
Wasanthi Wickramasinghe,
Revathi Raj,
Shama Goonatillake,
Anuja Abayadeera,
Malik Samarasinghe,
Jeewaka Galhenage,
Pavithra Aarewatte,
Devan Mendis,
Chandima Thevarapperuma,
Ruwangi Dissanayake,
Lallindra Gooneratne
Publication year - 2022
Publication title -
ceylon medical journal/the ceylon medical journal
Language(s) - English
Resource type - Journals
eISSN - 2386-1274
pISSN - 0009-0875
DOI - 10.4038/cmj.v67i1.9554
Subject(s) - medicine , sri lanka , sibling , transplantation , disease , haematopoiesis , bone marrow transplantation , stem cell , human leukocyte antigen , hematopoietic stem cell transplantation , bone marrow , pediatrics , surgery , immunology , genetics , psychology , developmental psychology , ethnology , south asia , antigen , biology , history
Bone marrow failure (BMF) in children can be idiopathic (70-80%) or inherited. Haematopoietic stem cell transplantation (HSCT) is the only cure for both causes. Allogeneic HSCT requires a suitable donor. Many children will not have a HLA matched sibling or unrelated donor. A haploidentical donor is available for all children as eaazch parent will have at minimum a 50% HLA match. This report of a 7-year old girl with BMF treated with a haplo-HSCT, the first in Sri Lanka, highlights the importance of developing a haploidentical HSCT programme as a potential cure for a disease with a dismal outcome.