Mechanical Ventilation Antioxidant Trial | Zendy

Kimberly Howe | Zendy; John M. Clochesy | Zendy; Lawrence S.B. Goldstein | Zendy; H. Owen | Zendy

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Mechanical Ventilation Antioxidant Trial

Author(s) -

Kimberly Howe,

John M. Clochesy,

Lawrence S.B. Goldstein,

H. Owen

Publication year - 2015

Publication title -

american journal of critical care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.592

H-Index - 81

eISSN - 1937-710X

pISSN - 1062-3264

DOI - 10.4037/ajcc2015335

Subject(s) - medicine , mechanical ventilation , ventilation (architecture) , randomized controlled trial , antioxidant , intensive care medicine , anesthesia , mechanical engineering , biochemistry , chemistry , engineering

Many patients each year require prolonged mechanical ventilation. Inflammatory processes may prevent successful weaning, and evidence indicates that mechanical ventilation induces oxidative stress in the diaphragm, resulting in atrophy and contractile dysfunction of diaphragmatic myofibers. Antioxidant supplementation might mitigate the harmful effects of the oxidative stress induced by mechanical ventilation.

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