Open AccessGranulomas Formation in Lymph Nodes, Liver and Spleen in Adult-Onset Still’s Disease: A Case Report
Author(s) -
Stelios F. Assimakopoulos,
Vasileios Karamouzos,
Christos Papakonstantinou,
Vassiliki Zolota,
Chryssoula Labropoulou-Karatza,
Charalambos Gogos
Publication year - 2013
Publication title -
journal of clinical medicine research
Language(s) - English
Resource type - Journals
eISSN - 1918-3011
pISSN - 1918-3003
DOI - 10.4021/jocmr1281e
Subject(s) - medicine , lymph , spleen , pathology , adult onset still's disease , context (archaeology) , etiology , disease , lymphatic system , immunology , paleontology , biology
Tissue granulomas formation in adult-onset Still's disease (AOSD) is extremely rare. We describe a case of AOSD associated with formation of granulomatous lesions in lymph nodes, liver and presumably spleen. The high dose steroid-dependent nature of our patient's illness, characterized by disease relapses when methylprednisolone dose was reduced below 10 mg/d, was overwhelmed with institution of anakinra (100 mg/d). The histologic finding of granulomas formation in lymph nodes, liver or spleen should not deter the consideration of AOSD as a potential diagnosis in a compatible clinical context; however, other more common etiologies of tissue granulomas formation should be first excluded.