Open AccessProlyl Isomerase Pin1 Expression in the Spinal Motor Neurons of Patients With Sporadic Amyotrophic Lateral Sclerosis
Author(s) -
Haruhisa Kato,
Makiko Naito,
Tomoko Saito,
Takuto Hideyama,
Yoshiaki Suzuki,
Takashi Kimura,
Shin Kwak,
Hitoshi Aizawa
Publication year - 2022
Publication title -
journal of clinical neurology/the journal of clinical neurology
Language(s) - English
Resource type - Journals
eISSN - 2005-5013
pISSN - 1738-6586
DOI - 10.3988/jcn.2022.18.4.463
Subject(s) - pin1 , amyotrophic lateral sclerosis , motor neuron , spinal cord , peptidylprolyl isomerase , prolyl isomerase , biology , cytoplasm , pathology , microbiology and biotechnology , neuroscience , medicine , isomerase , gene , disease , genetics
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease. Selective deficiency of edited adenosine deaminase acting on RNA 2 (ADAR2), a key molecule in the acquisition of Ca 2+ resistance in motor neurons, has been reported in sporadic ALS (sALS) spinal motor neurons. Since ADAR2 activity is positively regulated by prolyl isomerase Protein never in mitosis gene A interacting-1 (Pin1), a known phosphorylation-dependent peptidyl-prolyl cis/trans isomerase, we investigated Pin1 expression in spinal motor neurons in sALS.