Open AccessParamagnetic Rims in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Quantitative Susceptibility Mapping Study with 3-T MRI
Author(s) -
Jinhee Jang,
Yoonho Nam,
Yangsean Choi,
NaYoung Shin,
Jae Young An,
Kook Jin Ahn,
Bum Soo Kim,
Kwang Soo Lee,
Woojun Kim
Publication year - 2020
Publication title -
journal of clinical neurology/the journal of clinical neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.208
H-Index - 45
eISSN - 2005-5013
pISSN - 1738-6586
DOI - 10.3988/jcn.2020.16.4.562
Subject(s) - multiple sclerosis , quantitative susceptibility mapping , medicine , magnetic resonance imaging , neuromyelitis optica , spectrum disorder , radiology , nuclear medicine , pathology , immunology , psychiatry
Iron retained by activated microglia and macrophages in multiple sclerosis (MS) lesions may serve as a marker of innate immune system activation. Among several magnetic resonance imaging (MRI) methods, there has been recent interest in using quantitative susceptibility mapping (QSM) as a potential tool for assessing iron levels in the human brain. This study examined QSM findings in MS and neuromyelitis optica spectrum disorder (NMOSD) lesions obtained with 3-T MRI to assess imaging characteristics related to paramagnetic rims around brain lesions in MS and NMOSD.