Open Access8-Endo-Selective Aryl Radical Cyclization Leading to 3-Benzazocines
Author(s) -
Hiroyuki Ishibashi,
Tsuyoshi Taniguchi,
Hisaaki Zaimoku
Publication year - 2009
Publication title -
heterocycles
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.242
H-Index - 64
eISSN - 1881-0942
pISSN - 0385-5414
DOI - 10.3987/com-08-s(f)21
Subject(s) - chemistry , radical cyclization , aryl radical , aryl , free radical reaction , medicinal chemistry , stereochemistry , radical , organic chemistry , alkyl
Bu3SnH-mediated radical cyclization of N-acyl-3-(2-bromophenyl)-N-ethenypropylamines (14) occurred in an endo-selective manner to give the 3-benzazocine derivatives (15) in good yields. © 2009 The Japan Institute of Heterocyclic Chemistry All rights reserved
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