Open AccessTumor necrosis factor (TNF) induces astrogliosis, microgliosis and promotes survival of cortical neurons
Author(s) -
Ebtesam M. Abd-El-Basset,
Muddanna S. Rao,
Solaiman M Alshawaf,
Hasan Ashkanani,
Abdulaziz H Kabli
Publication year - 2021
Publication title -
aims neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 12
eISSN - 2373-7972
pISSN - 2373-8006
DOI - 10.3934/neuroscience.2021031
Subject(s) - astrogliosis , microglia , tumor necrosis factor alpha , neurodegeneration , gliosis , astrocyte , glial fibrillary acidic protein , medicine , pathology , intraperitoneal injection , endocrinology , inflammation , central nervous system , immunohistochemistry , disease
Neuro-inflammation occurs as a sequence of brain injury and is associated with production of cytokines. Cytokines can modulate the function and survival of neurons, microglia and astrocytes. The objective of this study is to examine the effect of TNF on the neurons, microglia and astrocytes in normal brain and stab wound brain injury.