Open AccessDown syndrome: A curative prospect?
Author(s) -
Jean-Adolphe Rondal
Publication year - 2020
Publication title -
aims neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.257
H-Index - 12
eISSN - 2373-7972
pISSN - 2373-8006
DOI - 10.3934/neuroscience.2020012
Subject(s) - etiology , disease , pathological , down syndrome , psychology , medicine , neuroscience , bioinformatics , biology , pathology , psychiatry
Experimental work regarding corrective actions on chromosomes and genes, and control of gene products is yielding promising results. It opens the way to advances in dealing with the etiological aspects of Down syndrome and may lead to important changes in the life of individuals affected with this condition. A small number of molecules are being investigated in pharmacological research that may have positive effects on intellectual functioning. Studies of the pathological consequences of the amyloid cascade and the TAU pathology in the etiology of Alzheimer disease (AD), which is more frequent and occuring earlier in life in persons with Down syndrome (DS), are presented. The search for biological markers of AD and ways for constrasting its early manifestations are also discussed.