Open AccessMethicillin-resistant Staphylococcus aureus as a cause of chronic wound infections: Alternative strategies for management
Author(s) -
Oriana Simonetti,
Samuele Marasca,
Matteo Candelora,
Giulio Rizzetto,
Giulia Radi,
Elisa Molinelli,
Lucia Brescini,
Oscar Cirioni,
Annamaria Offidani
Publication year - 2022
Publication title -
aims microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.565
H-Index - 6
ISSN - 2471-1888
DOI - 10.3934/microbiol.2022011
Subject(s) - biofilm , staphylococcus aureus , microbiology and biotechnology , virulence , antibiotics , antibiotic resistance , in vivo , medicine , biology , bacteria , gene , biochemistry , genetics
Biofilm formation at the level of a wound plays an important role in its chronicization. The difficulty of its eradication has driven research toward the discovery and synthesis of new molecules that can act on biofilm to promote wound healing. This narrative review focuses on alternative molecules that can act and promote the eradication of methicillin-resistant Staphylococcus aureus , taking into consideration its antibiotic resistance, virulence, tendency toward the tenacious colonization of wounds by biofilms, and its increased prevalence in both community and hospital settings. A selection of promising studies were reported, analyzing the in vitro and/or in vivo efficacy of bacteriophages, metal nanoparticles, RNAIII inhibiting peptide (RIP), synthetized RIP derivatives, proteinase K and hamamelitannin.