Open AccessAn age-structured epidemic model with boosting and waning of immune status
Author(s) -
Kento Okuwa,
Hisashi Inaba,
Toshikazu Kuniya
Publication year - 2021
Publication title -
mathematical biosciences and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 45
eISSN - 1551-0018
pISSN - 1547-1063
DOI - 10.3934/mbe.2021289
Subject(s) - bifurcation , boosting (machine learning) , immune system , basic reproduction number , steady state (chemistry) , disease , biology , mathematics , physics , medicine , immunology , computer science , artificial intelligence , population , environmental health , chemistry , quantum mechanics , nonlinear system
In this paper, we developed an age-structured epidemic model that takes into account boosting and waning of immune status of host individuals. For many infectious diseases, the immunity of recovered individuals may be waning as time evolves, so reinfection could occur, but also their immune status could be boosted if they have contact with infective agent. According to the idea of the Aron's malaria model, we incorporate a boosting mechanism expressed by reset of recovery-age (immunity clock) into the SIRS epidemic model. We established the mathematical well-posedness of our formulation and showed that the initial invasion condition and the endemicity can be characterized by the basic reproduction number $ R_0 $. Our focus is to investigate the condition to determine the direction of bifurcation of endemic steady states bifurcated from the disease-free steady state, because it is a crucial point for disease prevention strategy whether there exist subcritical endemic steady states. Based on a recent result by Martcheva and Inaba [1] , we have determined the direction of bifurcation that endemic steady states bifurcate from the disease-free steady state when the basic reproduction number passes through the unity. Finally, we have given a necessary and sufficient condition for backward bifurcation to occur.