Long non-coding RNA XIST is down-regulated and correlated to better prognosis in ovarian cancer | Zendy

Yue Hu | Zendy; Xiaoqin Mei | Zendy; Dong Tang | Zendy

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Long non-coding RNA XIST is down-regulated and correlated to better prognosis in ovarian cancer

Author(s) -

Yue Hu,

Xiaoqin Mei,

Dong Tang

Publication year - 2020

Publication title -

mathematical biosciences and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.451

H-Index - 45

eISSN - 1551-0018

pISSN - 1547-1063

DOI - 10.3934/mbe.2020110

Subject(s) - xist , ovarian cancer , biology , rna , long non coding rna , transcription (linguistics) , cancer research , cancer , x inactivation , medicine , oncology , x chromosome , genetics , gene , linguistics , philosophy

Ovarian cancer (OC) is one of the most common gynecological malignant tumors. Understanding the molecular mechanisms involved in the development of ovarian cancer is helpful for the diagnosis and treatment of OC. In this study, we found that lncRNA XIST was significantly overexpressed in normal ovarian tissues and down-regulated in OC. Moreover, we showed XIST was associated with the development of OC and down-regulated in advanced stage OC compared to early-stage OC samples. Overexpression of XIST was significantly associated with longer survival in patients with OC. Also, our analysis also showed that lncRNA XIST was closely related to biological processes such as transcription, protein phosphorylation, transport, protein ubiquitination, and DNA repair. To further reveal the function and role of XIST in OC, we constructed a protein-protein interaction network and an endogenous competitive RNA network. The present study provided a theoretical basis for the diagnosis and treatment of OC.

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