Open AccessPulsatile flow through idealized renal tubules: Fluid-structure interaction and dynamic pathologies
Author(s) -
Niksa Praljak,
Shawn D. Ryan,
Andrew Resnick
Publication year - 2020
Publication title -
mathematical biosciences and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 45
eISSN - 1551-0018
pISSN - 1547-1063
DOI - 10.3934/mbe.2020094
Subject(s) - pulsatile flow , mechanics , nephron , fluid dynamics , flow (mathematics) , fluid–structure interaction , finite element method , coupling (piping) , autosomal dominant polycystic kidney disease , kidney , physics , materials science , medicine , thermodynamics , metallurgy
Kidney tubules are lined with flow-sensing structures, yet information about the flow itself is not easily obtained. We aim to generate a multiscale biomechanical model for analyzing fluid flow and fluid-structure interactions within an elastic kidney tubule when the driving pressure is pulsatile. We developed a two-dimensional macroscopic mathematical model of a single fluid-filled tubule corresponding to a distal nephron segment and determined both flow dynamics and wall strains over a range of driving frequencies and wall compliances using finite-element analysis. The results presented here demonstrate good agreement with available analytical solutions and form a foundation for future inclusion of elastohydrodynamic coupling by neighboring tubules. Overall, we are interested in exploring the idea of dynamic pathology to better understand the progression of chronic kidney diseases such as Polycystic Kidney Disease.