Open AccessAn integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival
Author(s) -
Alexis B. Cook,
Daniel Ziazadeh,
Jianfeng Lu,
Trachette L. Jackson
Publication year - 2015
Publication title -
mathematical biosciences and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 45
eISSN - 1551-0018
pISSN - 1547-1063
DOI - 10.3934/mbe.2015.12.1219
Subject(s) - apoptosis , programmed cell death , cancer cell , cancer research , cancer , chemotherapy , cancer treatment , biology , genetics
Apoptosis resistance is a hallmark of human cancer, and tumor cells often become resistant due to defects in the programmed cell death machinery. Targeting key apoptosis regulators to overcome apoptotic resistance and promote rapid death of tumor cells is an exciting new strategy for cancer treatment, either alone or in combination with traditionally used anti-cancer drugs that target cell division. Here we present a multiscale modeling framework for investigating the synergism between traditional chemotherapy and targeted therapies aimed at critical regulators of apoptosis.