Open AccessCalculation of $R_0$ for age-of-infection models
Author(s) -
Christine K. Yang,
Fred Brauer
Publication year - 2008
Publication title -
mathematical biosciences and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 45
eISSN - 1551-0018
pISSN - 1547-1063
DOI - 10.3934/mbe.2008.5.585
Subject(s) - basic reproduction number , compartment (ship) , reproduction , expression (computer science) , mathematics , epidemic model , statistics , biology , demography , computer science , ecology , geology , population , oceanography , sociology , programming language
We consider age-of-infection epidemic models to describe multiple- stage epidemic models, including treatment. We derive an expression for the basic reproduction number R0 in terms of the distributions of periods of stay in the various compartments. We find that, in the model without treatment, R0 depends only on the mean periods in compartments, and not on the form of the distributions. In treatment models, R0 depends on the form of the distributions of stay in infective compartments from which members are removed for treatment, but the dependence for treatment compartments is only on the mean stay in the compartments. The results give a considerable simplification in the calculation of the basic reproduction number.